Keveyis® is the first and only FDA-approved treatment for hyperkalemic, hypokalemic, and related variants of Primary Periodic Paralysis.1

In clinical studies, the most common side effects of Keveyis® (dichlorphenamide) 50 mg tablets were a tingling or pricking sensation, difficulty thinking and paying attention, changes in taste, and confusion.1

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Keveyis is proven to reduce primary periodic paralysis attacks.1

Keveyis has been shown in studies to reduce the number of attacks of muscle weakness in people with primary hyperkalemic and hypokalemic periodic paralysis and related variants.1

Keveyis is not for everyone. Do not take Keveyis if you are on a high-dose aspirin regimen, are allergic to sulfa-based drugs, have liver, kidney, or certain lung conditions, or are pregnant, planning to become pregnant, or nursing.1

Make an appointment to talk to your healthcare provider about Keveyis.

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Keveyis is a tablet taken twice a day.1

The amount of Keveyis you will take is based on your specific needs. The recommended starting dose is 50 mg taken twice a day. Your healthcare provider may decide to adjust your dose over time depending on how you respond to Keveyis and whether or not you experience side effects.1

You should notify your healthcare provider if you experience worsening of symptoms of primary periodic paralysis.1

Questions about Keveyis?

If you are a patient or healthcare provider with questions about how to fill a prescription for Keveyis (dichlorphenamide), or if you have any other questions related to Keveyis, call 844-KEVEYIS or fax to 844-KEV-1030.

Important Safety Information

What is KEVEYIS?

KEVEYIS (keh-VAY-iss) (dichlorphenamide) is a prescription drug used to treat primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and other similar diseases.

What should you tell your healthcare provider before taking KEVEYIS?

Tell your doctor if you are allergic to dichlorphenamide or other sulfur drugs; if you take high doses of aspirin, or if you have lung or liver disease; if you are pregnant, plan to become pregnant, or are breastfeeding or plan to breastfeed.

What should you know about KEVEYIS?

  • Severe allergic and other reactions have happened with sulfonamides (drugs such as KEVEYIS) and have sometimes been fatal. Stop taking KEVEYIS at the first sign of skin rash, swelling, difficulty breathing, or any other unexpected side effect or reaction, and call 911 right away.
  • Tell your healthcare provider if you take aspirin or if another healthcare provider instructs you to begin taking aspirin. High doses of aspirin should not be taken with KEVEYIS.
  • KEVEYIS can cause your body to lose potassium, which can lead to heart problems. Your healthcare provider will measure the potassium levels in your blood before you start treatment and at certain times during treatment.
  • Tell your healthcare provider about all other prescription and over-the-counter medicines you take, including supplements, as some medicines can interact with KEVEYIS.
  • While taking KEVEYIS, your body may produce too much acid or may not be able to remove acid from the body. Your healthcare provider may run tests on a regular basis to check for signs of acid buildup.
  • KEVEYIS may increase your risk of falling. Tell your healthcare provider right away if you experience a fall while taking KEVEYIS.
  • The risks of falls and acid buildup are greater in elderly patients.
  • It is not known whether KEVEYIS is safe or effective for people younger than 18 years of age.

What are the most common side effects with KEVEYIS?

The most common side effects are a feeling of numbness, tingling or burning (“pins and needles”) in the toes, feet, hands or fingers; trouble with memory or thinking; feeling confused; and unpleasant taste in the mouth.

These are not all of the possible side effects of KEVEYIS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

Please see Prescribing Information (PDF).

 1. KEVEYIS Prescribing Information. Trevose, PA: Strongbridge Biopharma; 2015.