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Finding out how KEVEYIS can help you

How has KEVEYIS been proven to treat PPP?

KEVEYIS has been shown to reduce the number, severity, and length of PPP episodes in 2 separate clinical studies.1,2

It is the first drug approved by the FDA for the treatment of PPP.1 Be sure to talk to your doctor about what you can expect when you start taking KEVEYIS.

Everyone who takes KEVEYIS has different treatment goals, so work with your doctor to decide on goals that are right for you—for example, reducing how many episodes you have. Be sure to check in with your doctor regularly so he or she can see if KEVEYIS is working for you.

When compared with placebo (an inactive pill) in one study…2

KEVEYIS has been studied in 2 separate clinical studies and was proven to be an effective treatment for Primary Periodic Paralysis.1,2

Number of PPP episodes decreased
People taking KEVEYIS had significantly fewer weekly episodes.2

Episodes were shorter
When patients taking KEVEYIS did have episodes, they didn’t last as long.2

Episodes were not as severe
Patients were asked to rate the severity of their episodes using a scale from 1 (not severe) to 10 (extremely severe).2 Patients taking KEVEYIS reported that their episodes were not as severe.2

A second study confirmed the results of the first study.1

What are the most common side effects with KEVEYIS?

In the key clinical study, some of the most common side effects of KEVEYIS were1:

Tingling or prickling sensations (“pins and needles”)

Confusion or trouble paying attention

Changes in taste

Brain fog


How do you take KEVEYIS?

You take KEVEYIS by mouth once or twice daily, depending on what your doctor has prescribed.1

Your doctor determined how much KEVEYIS you should take every day based on your specific needs, which may be different from how much KEVEYIS someone else takes.1

Treatment with KEVEYIS is personalized, so your doctor can change your dose to find what’s right for you.1

Tips for taking KEVEYIS.1

KEVEYIS is a pill that you take by mouth once or twice daily, depending on what your doctor has prescribed. To help you get the most out of your treatment, remember:

  • It’s important that you take KEVEYIS every day
  • Skipping doses can lead to episodes of muscle weakness and/or temporary paralysis
  • If you forget a dose, take your next dose as scheduled. Don’t take more than the prescribed amount
  • Track any episodes you have in your phone or on paper—your doctor will want to know if you’re still having episodes so that he or she can consider increasing your daily dose of KEVEYIS

Finding the right dose for you

Everyone experiences PPP differently. It’s completely normal for your doctor to increase or decrease how much KEVEYIS you’re taking depending on how you’re feeling when you’re taking KEVEYIS.1 That’s why it’s important to keep your doctor informed.

  • If you’re experiencing side effects that you can’t manage, your doctor may decrease your daily dose of KEVEYIS
  • If you’re still experiencing episodes of muscle weakness or paralysis, your doctor may increase your daily dose of KEVEYIS

Remember: it’s important to keep your doctor informed throughout your treatment about any side effects you may experience, or if you are still having episodes.

Follow up with your doctor

Once you start taking KEVEYIS, make sure you have a follow-up appointment to check in with your doctor.
Learn about PPP.
Find a doctor who specializes in PPP and KEVEYIS.

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Indication and Important Safety Information

What is KEVEYIS?

KEVEYIS (pronounced keh-VAY-iss) (dichlorphenamide) is a prescription drug used to treat primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and other similar diseases.

What should you tell your healthcare provider before taking KEVEYIS?

Tell your doctor if you are allergic to dichlorphenamide or other sulfa drugs; if you take high doses of aspirin, or if you have lung or liver disease; if you are pregnant, plan to become pregnant, or are breastfeeding or plan to breastfeed.

What should you know about KEVEYIS?

  • Severe allergic and other reactions have happened with sulfonamides (drugs such as KEVEYIS) and have sometimes been fatal. Stop taking KEVEYIS at the first sign of skin rash, swelling, difficulty breathing, or any other unexpected side effect or reaction, and call 911 right away.
  • Tell your healthcare provider if you take aspirin or if another healthcare provider instructs you to begin taking aspirin. High doses of aspirin should not be taken with KEVEYIS.
  • KEVEYIS can cause your body to lose potassium, which can lead to heart problems. Your healthcare provider will measure the potassium levels in your blood before you start treatment and at certain times during treatment.
  • Tell your healthcare provider about all other prescription and over-the-counter medicines you take, including supplements, as some medicines can interact with KEVEYIS.
  • While taking KEVEYIS, your body may produce too much acid or may not be able to remove acid from the body. Your healthcare provider may run tests on a regular basis to check for signs of acid buildup.
  • KEVEYIS may increase your risk of falling. Tell your healthcare provider right away if you experience a fall while taking KEVEYIS.
  • The risks of falls and acid buildup are greater in elderly patients.
  • It is not known whether KEVEYIS is safe or effective for people younger than 18 years of age.

What are the most common side effects with KEVEYIS?

The most common side effects are a feeling of numbness, tingling or burning (“pins and needles”) in the toes, feet, hands or fingers; trouble with memory or thinking; feeling confused; and unpleasant taste in the mouth.

These are not all of the possible side effects of KEVEYIS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Full Prescribing Information.

References

  1. KEVEYIS [package insert]. Chicago, IL; Xeris Pharmaceuticals.
  2. Sansone VA, Burge J, McDermott MP, et al; for the Muscle Study Group. Randomized, placebo-controlled trials of dichlorphenamide in periodic paralysis. Neurology. 2016;86:1408-1416.