Important Safety Information

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Manage your
Primary Periodic Paralysis
today — and for the future

PATIENT TESTIMONIAL

“For someone...with PPP, there really is hope. Things can be so much better once you have a treatment plan in place.”

Janine, KEVEYIS Patient and PPP Mentor

Finding the right PPP treatment plan

You may face a lot of stress as you try to find a diagnosis and treatment plan for PPP. The good news is that developing a treatment plan focused on both today and the future can help.

Work with your doctor to find the best PPP treatment plan for you. Remember that your treatment plan should include long-term attack prevention strategies and guidance for managing episodes when they arise.1

The importance of preventing PPP attacks

Therapeutic options that reduce the number and severity of PPP episodes are recommended for long-term maintenance.1 Preventing attacks through medication may help you gain more control over your PPP and engage more fully in life.

KEVEYIS is proven to help reduce the number, severity and duration of PPP attacks.2,3

Learn more about KEVEYIS

Know your triggers — and manage them

Certain factors, known as triggers, can cause a PPP episode.1 In addition to preventing attacks with medication, learning to identify your triggers can help you better manage episodes. Common triggers include:

  • Food or beverages high in salt, carbohydrates or potassium
  • Stress or tiredness
  • Becoming cold
  • Periods of inactivity
  • Resting after exercise

Treat an oncoming or current attack

You may be able to gain greater control over your PPP episodes using the below tips.1,4,6 Talk to your doctor about the best PPP management plan for you.

Hypokalemic Primary Periodic Paralysis (HypoPPP)

PPP episodes may involve a decrease in potassium levels.1,4

Take potassium supplements as recommended by a healthcare provider.1,4 Eat a low sodium, low carbohydrate diet.

Hyperkalemic Primary Periodic Paralysis (HyperPPP)

PPP episodes may involve an increase in potassium levels.1,4 In some cases, potassium levels are normal during an episode.1

Eat frequent carbohydrate-heavy meals.1,4 Avoid potassium-rich foods.

Paramyotonia Congenita (PMC)

Attacks of muscle stiffness that occur during activity such as exercise5

Avoid cold temperatures and strenuous exercise4

Andersen-Tawil syndrome (ATS)

Characterized by muscle weakness, changes in heartbeat, and distinct skeletal features.1,6 It is associated with low, normal, or high potassium levels during an episode.

Light exercise may help decrease the severity of an episode6

PATIENT TESTIMONIAL

"Be patient with yourself, be forgiving... There are all sorts of help, advice, tools available to manage [PPP] and things will improve."

Paul, KEVEYIS Patient and PPP Mentor

Keep track of your episodes

Use the Daily Tracker Tool to record details of your PPP episodes. This can help you determine if something is a trigger or if a management strategy is working. The tracker also includes a 1-Month Diary.

Download the Daily Tracker

Stay up to date on PPP information

Access the latest information to help you gain more control over PPP.

Connect with a Patient Access Manager

References

  1. Statland JM, Fontaine B, Hanna MG, et al. Review of the diagnosis and treatment of periodic paralysis. Muscle Nerve. 2018;57:522-530.
  2. KEVEYIS [package insert]. Chicago, IL; Xeris Pharmaceuticals.
  3. Sansone VA, Burge J, McDermott MP, et al; for the Muscle Study Group. Randomized, placebo-controlled trials of dichlorphenamide in periodic paralysis. Neurology. 2016;86:1408-1416.
  4. Ralph J, Ptacek L. Muscle channelopathies: periodic paralyses and nondystrophic myotonias. In: Rosenberg RN, Pascual JM, eds. Rosenberg’s Molecular and Genetic Basis of Neurological and
  5. Psychiatric Disease. 5th ed. Elsevier; 2015:1177- 1189.
    Paramyotonia Congenita. MedlinePlus. Updated August 1, 2015. Accessed June 4, 2024. https://medlineplus.gov/genetics/condition/paramyotonia-congenita/#causes
  6. Veerapandiyan A, Statland JM, Tawil R. Andersen-Tawil Syndrome. In: Adam MP, Ardinger HH, Pagon RA, et al, eds. GeneReviews®. University of Washington, Seattle; 1993-2019. Updated June 7, 2018. Accessed March 22, 2024. https://www.ncbi.nlm.nih.gov/books/NBK1264/.

INDICATION AND IMPORTANT SAFETY INFORMATION — READ MORE

Indication and Important Safety Information

 

What is KEVEYIS?

KEVEYIS (pronounced keh-VAY-iss) (dichlorphenamide) is a prescription drug used to treat primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and other similar diseases.

 

What should you tell your healthcare provider before taking KEVEYIS?

Tell your doctor if you are allergic to dichlorphenamide or other sulfa drugs; if you take high doses of aspirin, or if you have lung or liver disease; if you are pregnant, plan to become pregnant, or are breastfeeding or plan to breastfeed.

 

What should you know about KEVEYIS?

  • Severe allergic and other reactions have happened with sulfonamides (drugs such as KEVEYIS) and have sometimes been fatal. Stop taking KEVEYIS at the first sign of skin rash, swelling, difficulty breathing, or any other unexpected side effect or reaction, and call 911 right away.
  • Tell your healthcare provider if you take aspirin or if another healthcare provider instructs you to begin taking aspirin. High doses of aspirin should not be taken with KEVEYIS.
  • KEVEYIS can cause your body to lose potassium, which can lead to heart problems. Your healthcare provider will measure the potassium levels in your blood before you start treatment and at certain times during treatment.
  • Tell your healthcare provider about all other prescription and over-the-counter medicines you take, including supplements, as some medicines can interact with KEVEYIS.
  • While taking KEVEYIS, your body may produce too much acid or may not be able to remove acid from the body. Your healthcare provider may run tests on a regular basis to check for signs of acid buildup.
  • KEVEYIS may increase your risk of falling. Tell your healthcare provider right away if you experience a fall while taking KEVEYIS.
  • The risks of falls and acid buildup are greater in elderly patients.
  • It is not known whether KEVEYIS is safe or effective for people younger than 18 years of age.

 

What are the most common side effects with KEVEYIS?

The most common side effects are a feeling of numbness, tingling or burning (“pins and needles”) in the toes, feet, hands or fingers; trouble with memory or thinking; feeling confused; and unpleasant taste in the mouth.

These are not all of the possible side effects of KEVEYIS. Call your healthcare provider for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see Full Prescribing Information.

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